ABSTRACT
Traditional villages are a valuable cultural asset that occupy an important position in Chinese traditional culture. This study focuses on 206 traditional villages in Hebei Province and aims to explore their spatial distribution characteristics and influencing factors using ArcGIS spatial analysis. The analysis shows that traditional villages in Hebei Province were distributed in clusters during different historical periods, and eventually formed three core clusters in Shijiazhuang, Zhangjiakou and Xingtai-Handan after different historical periods. Moreover, the overall distribution of traditional villages in Hebei Province is very uneven, with clear regional differences, and most of them are concentrated in the eastern foothills of the Taihang Mountains. To identify the factors influencing traditional villages, natural environmental factors, socio-economic factors, and historical and cultural factors are considered. The study finds that socio-economic and natural environmental factors alternate in the spatial distribution of traditional villages in Hebei Province. The influence of the interaction of these factors increases significantly, and socio-economic factors have a stronger influence on the spatial distribution. Specifically, the spatial distribution of traditional villages in Hebei Province is influenced by natural environmental factors, while socio-economic factors act as drivers of spatial distribution. Historical and cultural factors act as catalysts of spatial distribution, and policy directions are external forces of spatial distribution. Overall, this study provides valuable insights into the spatial distribution characteristics and influencing factors of traditional villages in Hebei Province, which can be used to develop effective strategies for rural revitalisation in China.
ABSTRACT
SARS-CoV-2 enters the respiratory tract where it infects the alveoli epithelial lining. However, patients have sequelae that extend well beyond the alveoli into the pulmonary vasculature and perhaps beyond to brain and other organs. Because of the dynamic events within blood vessels, histology fails to report on platelet and neutrophil dynamics. Because of the rapid non-transcriptional behaviour of these cells neither single-cell RNAseq nor proteomics report robustly on their critical behaviours. We used intravital-microscopy in level-3 containment to examine the pathogenesis of SARS-CoV-2 within three organs in mice expressing human-ACE-2 ubiquitously (CAG-AC-70) or on epithelium (K18-promoter). Using a neon-green-SARS-CoV-2, we observed both epithelium and endothelium infected in AC70 mice but only the epithelium in K18 mice. There was increased neutrophils in the microcirculation but not in the alveoli of the AC70 lungs. Platelets formed large aggregates in the pulmonary capillaries. Despite only neurons being infected within the brain, profound neutrophil adhesion forming the nidus of large platelet aggregates were observed in the brain microcirculation with many non-perfused microvessels. Neutrophils were seen breaching the brain endothelial layer associated with a significant disruption of the blood-brain-barrier. Despite ubiquitous ACE-2 expression, CAG-AC-70 mice had very small increases in blood cytokine, no increase in thrombin, no infected circulating cells and no liver involvement suggesting limited systemic effects. In summary, our imaging of SARS-CoV-2-infected mice gave direct evidence that there is a significant perturbation locally in the lung and brain microcirculation induced by local viral infection leading to increased inflammation and thrombosis in these organs.
ABSTRACT
During the COVID-19 pandemic, business managers are facing many challenges from a severe challenge. Many organizations have changed their original management mode and organizational behavior to improve employees' organizational citizenship behavior, thus reducing their sense of anxiety and incapability. Thereinto, job performance of the employees also affects the growth and development of the organization. To explore how to fragment employees' positive psychology and job performance, this study discusses the influence on employees' subjective wellbeing and job performance from relevant factors at the organizational and individual levels. Also, to explore the influence of organizational support and occupation self-efficacy on job performance and the mediating role of subjective wellbeing during COVID-19, a total of 618 valid questionnaires were collected from all walks of life in 2020. Hypotheses were tested by structural equation modeling and Bootstrap technology. The results show that: (1) Professional self-efficacy and subjective wellbeing have a significant positive impact on job performance; (2) Subjective wellbeing plays a complete mediating role between organizational support and job performance, and subjective wellbeing plays a partial mediating role between professional self-efficacy and job performance; (3) Compared with the sense of organizational support, the positive effect of self-efficacy on job performance is more significant.
ABSTRACT
Medical wastewater originating from hospitals specializing in infectious diseases pose a major risk to human and environmental health during pandemics. However, there have been few systematic studies on the management of this type of wastewater management. The function of the Huoshenshan Hospital as a designated emergency field hospital for the treatment of COVID-19 has provided lessons for the management measures of medical wastewater, mainly including: (1) Modern information technology, management schemes, and related standard systems provided the legislative foundation for emergency management of medical wastewater. (2) The three-tier prevention and control medical wastewater management system ensured the discharged wastewater met water quality standards, especially for the leak-proof sealed collection system of the first tier, and the biological and chemical treatment technology of the second tier. (3) The establishment of an effective three-tier medical wastewater quality monitoring accountability system. This system was particularly relevant for ensuring continuous data monitoring and dynamic analysis of characteristic indicators. (4) Information disclosure by government and public supervision promoted successful implementation of medical wastewater management and control measures. Public questionnaires (n = 212) further confirmed the effectiveness of information disclosure. The results of this study can act as methodological reference for the emergency management of wastewater in designated infectious disease hospitals under similar situations.
Subject(s)
COVID-19 , Communicable Diseases , China , Communicable Diseases/epidemiology , Hospitals , Humans , SARS-CoV-2 , WastewaterABSTRACT
BACKGROUND: Swine coccidiosis, a protozoan disease caused by coccidia, can result in diarrhoea and weight loss in piglets and even economic losses in the pig industry. Here, we report the first systematic review and meta-analysis of the prevalence of coccidia (including Eimeria spp. and Cystoisospora suis) in pigs in China. METHODS: Five databases (PubMed, ScienceDirect, Chinese Web of Knowledge, Wanfang, and Chongqing VIP) were searched and 50 studies (46,926 domestic pigs, 22 provinces) ultimately identified pertaining to the prevalence of coccidia infection from 1980 to 2019. We incorporated the effect size using the random-effects model in the "meta" package in R software and conducted univariate and multivariate meta-regression analyses using a mixed-effects model. RESULTS: The pooled prevalence rate of coccidia in pigs was 21.9%, including the C. suis infection rate of 9.1%. The highest prevalence of coccidia (39.6%) was found in northwest China, and this region also presented the lowest prevalence of C. suis (4.7%). In the subgroup analysis based on sampling year, the highest prevalence of coccidia was detected in 2001 or earlier (32.6%), whereas the lowest rate was found in 2012 or later (14.3%). An opposite trend was observed for C. suis (5.5% in 2000 or earlier vs 14.4% in 2000 or later). The prevalence of coccidia in extensive farming systems (29.5%) was higher than that in intensive farming systems (17.3%). In contrast, the point estimate of C. suis prevalence was lower in the extensive farming systems (5.1%) than in the intensive farming systems (10.0%), but the difference was not significant (P > 0.05). Among the four age categories, the highest total coccidia prevalence (26.2%) was found in finishing pigs, followed by suckling piglets (19.9%), whereas the highest prevalence of C. suis (14.9%) was observed in suckling piglets. CONCLUSIONS: Our findings suggest that coccidia infection in Chinese pigs is common, although the prevalence of C. suis in pigs does not receive sufficient attention. We recommend the rational use of anticoccidial drugs to avoid drug resistance and the development of preventive and control measures for C. suis to reduce the incidence of swine coccidiosis.